绉戝瀹跺湪鐧岀棁濡備綍閫冮伩鍏嶇柅绯荤粺鏂归潰鍙栧緱鏂拌繘灞�

杩戞棩锛屽彂琛ㄥ湪銆奛ature Communications銆嬩笂鐨勪竴椤规柊鐮旂┒涓紝鏉ヨ嚜鏂板姞鍧″浗绔嬬檶鐥囦腑蹇冦€佹潨鍏�-鏂板姞鍧″浗绔嬪ぇ瀛﹀尰瀛﹂櫌绛夊瀹跺鏈満鏋勭殑鑱斿悎鐮旂┒鍥㈤槦鍙戠幇浜嗙檶鐥囧浣曢€冮伩鍏嶇柅绯荤粺鍚庡湪浣撳唴杞Щ鐨勬満鍒讹紝骞舵帰绱簡鎶戝埗杩欎竴鍗遍櫓鏈哄埗鐨勫彲鑳芥€с€傝鐮旂┒瀵瑰紑鍙戠檶鐥囨不鐤楃殑鏂扮瓥鐣ュ叿鏈夐噸瑕佹剰涔夈€�

鐮旂┒鍥㈤槦浣跨敤绉绘鏈夎浆绉诲墠鐧岀粏鑳炵殑灏忛紶妯″瀷锛屼竴缁勪娇鐢ㄦ姉PD1娌荤枟锛屽彟涓€缁勪綔涓哄鐓э紝骞跺垎鏋愪簡琛ㄨ揪涓湡鍥犲瓙锛圡DK锛夊彈浣撶殑CD8+ T缁嗚優浜氱兢銆傜爺绌朵汉鍛樺彂鐜帮紝鍗充娇鍦ㄦ姉PD1娌荤枟鍚庯紝琛ㄨ揪MDK鍙椾綋鐨凜D8+ T缁嗚優涔熶細澧炲姞锛岃繖琛ㄦ槑MDK淇″彿閫氳矾浼氭縺鍙戝厤鐤姂鍒讹紝浠庤€屾秷闄ゆ姉PD1娌荤枟鐨勬晥鏋溿€�

杩欎簺鍙戠幇鎻ず浜哅DK淇″彿閫氳矾鏄浆绉诲墠鐧岀粏鑳炵敤鏉ラ€冮伩CD8+ T缁嗚優浠嬪鐨勫厤鐤洃娴嬬殑涓€绉嶉€斿緞锛岃鐮旂┒涔熻В閲婁簡涓€浜涙偅鑰呭鎶桺D1娌荤枟鐨勫弽搴斾笉濡傚彟涓€浜涙偅鑰呯殑鍘熷洜銆傜爺绌跺洟闃熻〃绀轰笅涓€姝ュ皢鎺㈢储鍙互涓庢姉PD1鐩哥粨鍚堢殑鐤楁硶锛屼互鎴愬姛瀵规姉琛ㄨ揪MDK鍙椾綋鐨凜D8+ T缁嗚優銆�

娉細姝ょ爺绌舵垚鏋滄憳鑷€奛ature Communications銆嬶紝鏂囩珷鍐呭涓嶄唬琛ㄦ湰缃戠珯瑙傜偣鍜岀珛鍦猴紝浠呬緵鍙傝€冦€�

鐭ュ墠娌匡紝闂櫤鐮斻€傛櫤鐮斿挩璇㈡槸涓浗涓€娴佷骇涓氬挩璇㈡満鏋勶紝鍗佹暟骞存寔缁繁鑰曚骇涓氱爺绌堕鍩燂紝鎻愪緵娣卞害浜т笟鐮旂┒鎶ュ憡銆佸晢涓氳鍒掍功銆佸彲琛屾€х爺绌舵姤鍛婂強瀹氬埗鏈嶅姟绛変竴绔欏紡浜т笟鍜ㄨ鏈嶅姟銆備笓涓氱殑瑙掑害銆佸搧璐ㄥ寲鐨勬湇鍔°€佹晱閿愮殑甯傚満娲炲療鍔涳紝涓撴敞浜庢彁渚涘畬鍠勭殑浜т笟瑙ｅ喅鏂规锛屼负鎮ㄧ殑鎶曡祫鍐崇瓥璧嬭兘銆�