绉戝瀹跺彂鐜癙NPLA3浠嬪鐨凬AFLD鍒嗗瓙鏈哄埗

闈為厭绮炬€ц剛鑲倽鐥咃紙NAFLD锛夋槸鍏ㄧ悆鏈€甯歌鐨勬參鎬ц倽鐥呭舰寮忥紝鏄寘鎷剛鑲彉鎬с€侀潪閰掔簿鎬ц剛鑲€ц倽鐐庛€佽倽纭寲鍜屾渶缁堢殑鑲濈粏鑳炵檶绛変竴绯诲垪鑲濊剰鐤剧梾鐨勬€荤О銆傚叾鍙戠敓鍙戝睍楂樺害鍙彉锛屼絾杩涘睍鏈哄埗灏氫笉娓呮櫚銆�

杩戞棩锛屽彂琛ㄥ湪銆奐ournal of Hepatology銆嬩笂鐨勪竴椤归涓衡€淚L6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease鈥濈殑鐮旂┒涓紝缇庡浗鍏嬪埄澶叞鍖诲涓績鍜屾礇鍏嬭彶鍕掑ぇ瀛︾爺绌朵汉鍛樺悎浣滃彂鐜颁簡浜哄惈Patatin鏍风７鑴傞叾鍩熻泲鐧�3锛圥NPLA3锛夎瀵肩殑NAFLD 鐤剧梾鍙戝睍鐨勫垎瀛愭満鍒躲€�

鐮旂┒浜哄憳鏋勫缓浜嗙被浼间簬浜虹被鍋ュ悍鑲濊剰鐨勫缁嗚優鑲濆煿鍏荤郴缁燂紝骞跺缓绔嬩簡PNPLA3WT 鎴� PNPLA3I148M鐨勫缁嗚優鑲濆煿鍏荤墿銆傚惈鏈塒NPLA3I148M 绐佸彉浣撶殑澶氱粏鑳炶倽鍩瑰吇鐗╁NAFLD 鐨勬槗鎰熸€ф洿寮恒€傝繘涓€姝ョ爺绌惰〃鏄庯紝澧炲己淇″彿杞崲鍜岃浆褰曟縺娲诲洜瀛�3(IL6/STAT3)淇″彿浼犲閫氳矾鍙互浣垮惈鏈塒NPLA3WT 鎴� PNPLA3I148M鐨勫缁嗚優鑲濆煿鍏荤墿瀵筃AFLD 鐨勬槗鎰熸€у鍔狅紝闃绘柇IL6/STAT3淇″彿鍙互鏈夋晥淇濇姢PNPLA3I148M璇卞鐨凬AFLD杩涘睍銆�

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https://www.journal-of-hepatology.eu/article/S0168-8278(22)03053-7/fulltext#relatedArticles

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