鎶戦儊鐥囷紙Depression锛夋槸涓€绉嶅父瑙佺殑绮剧闅滅锛屽叾鍒嗗瓙鏈哄埗灏氫笉娓呮锛岀己涔忓彲闈犵殑鐢熺墿鏍囧織鐗╋紝閮ㄥ垎鐥呬汉鐤楁晥涓嶄匠涓旀槗澶嶅彂锛岃繖浜涘洜绱犲叡鍚屽埗绾︿簡鎶戦儊鐥囩殑瀹㈣璇婃柇鍜屼复搴婃不鐤楃殑杩涘睍銆傛姂閮佺棁鐨勯珮鍙戝勾榫勬槸15锝�33宀侊紝涓€鑸コ鎬ф偅鐥呯巼楂樹簬鐢锋€с€傛棦寰€鐮旂┒鏄剧ず锛岀ぞ浼氬簲婵€锛圫ocial Stress锛夊彲鑳芥槸瀵艰嚧濂虫€ф姂閮佸彂鐢熺殑閲嶈鍥犵礌锛屼絾鍏跺叿浣撳垎瀛愭満鍒朵粛涓嶆竻妤氥€�
閲嶅簡鍖荤澶у鐮旂┒鍥㈤槦鏃㈠線鍩轰簬浣庣瓑绾ф姂閮佺尨妯″瀷鐨勭爺绌跺彂鐜帮細鑲犻亾寰敓鐗╅€氳繃鈥滆偁-鑴戔€濊酱璋冩帶鍓嶉鐨川锛圥FC锛夌敇娌圭7鑴備唬璋㈠彲浠嬪鎶戦儊琛屼负鍙戠敓銆傝繎鏈燂紝璇ュ洟闃熶负浜嗘繁鍏ユ帰绱㈠叾缁嗚優鐢熺墿瀛︽満鍒讹紝浣跨敤鍗曠粏鑳炴牳閰告祴搴忓拰绌洪棿杞綍缁勫鎶€鏈紝瀵归泴鎬т綆绛夌骇鎶戦儊鐚淬€佷綆绛夌骇闈炴姂閮佺尨鍜岄珮绛夌骇鐚寸殑鑳屼晶鍓嶉鍙剁毊灞傦紙dlPFC鍖猴級鍗曠粏鑳炶浆褰曡繘琛屼簡绯荤粺鍒嗘瀽锛屽彂鐜板皬鑳惰川缁嗚優鏄綆绛夌骇鎶戦儊鐚翠腑鏀瑰彉鐨勫叧閿粏鑳炵兢锛屽皢鍏跺懡鍚嶄负鈥滄姂閮佺浉鍏冲皬鑳惰川缁嗚優鈥濓紙PIMID锛夈€傝鍥㈤槦鍦ㄥ墠棰濆彾鐨眰缁忓吀瑙e墫瀛﹀垎灞備笂锛岃繕鏋勫缓浜嗗熀鍥犵殑鍒嗗瓙鍒嗗眰锛圫T1-4锛夛紝鍙戠幇涓よ€呴珮搴﹀鍚堬紝杩涜€屾彮绀轰簡涓嶅悓鐨勭┖闂村垎瀛愬垎灞傝皟鎺т笉鍚屾姂閮佽涓猴紝琛ㄧ幇涓衡€滅Н鏋佹儏缁殑鍑忓皯涓昏鍙桽T2-4璋冩帶鈥濄€佲€滄秷鏋佹儏缁殑澧炲姞涓昏鍙桽T1璋冩帶鈥濄€傝鐮旂┒瀹炵幇浜嗏€滃鏉傚姩鐗╄涓鸿〃鍨�-缁嗚優绫诲瀷-绌洪棿杞綍鍒嗗眰鈥濅箣闂寸殑鏈夋晥鏁村悎锛岀嫭鐗圭殑鍒嗘瀽鏂瑰紡鍙负璇ラ鍩熶粖鍚庣殑鐮旂┒鎻愪緵鍙傝€冦€傜浉鍏崇爺绌剁粨鏋滀簬2023骞�7鏈�13鏃ヤ互鈥淚ntegrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors鈥濅负棰樺彂琛ㄥ湪銆奛ature Neuroscience銆嬫潅蹇椾笂銆�
娉細姝ょ爺绌舵垚鏋滄憳鑷€奛ature Neuroscience銆嬶紝鏂囩珷鍐呭涓嶄唬琛ㄦ湰缃戠珯瑙傜偣鍜岀珛鍦恒€�
鐭ュ墠娌匡紝闂櫤鐮斻€傛櫤鐮斿挩璇㈡槸涓浗涓€娴佷骇涓氬挩璇㈡満鏋勶紝鍗佹暟骞存寔缁繁鑰曚骇涓氱爺绌堕鍩燂紝鎻愪緵娣卞害浜т笟鐮旂┒鎶ュ憡銆佸晢涓氳鍒掍功銆佸彲琛屾€х爺绌舵姤鍛婂強瀹氬埗鏈嶅姟绛変竴绔欏紡浜т笟鍜ㄨ鏈嶅姟銆備笓涓氱殑瑙掑害銆佸搧璐ㄥ寲鐨勬湇鍔°€佹晱閿愮殑甯傚満娲炲療鍔涳紝涓撴敞浜庢彁渚涘畬鍠勭殑浜т笟瑙e喅鏂规锛屼负鎮ㄧ殑鎶曡祫鍐崇瓥璧嬭兘銆�


2024-2030骞翠腑鍥藉尰鐤楀仴搴疯涓氬競鍦轰笓椤硅皟鐮斿強绔炰簤鎴樼暐鍒嗘瀽鎶ュ憡
銆�2024-2030骞翠腑鍥藉尰鐤楀仴搴疯涓氬競鍦轰笓椤硅皟鐮斿強绔炰簤鎴樼暐鍒嗘瀽鎶ュ憡銆嬪叡鍗佷簩绔狅紝鍖呭惈涓浗鍖荤枟鍋ュ悍琛屼笟閲嶇偣浼佷笟鍙戝睍璋冪爺锛�2024-2030骞翠腑鍥藉尰鐤楀仴搴峰競鍦洪娴嬪強鍙戝睍寤鸿锛屽尰鐤楀仴搴疯涓氱爺绌剁粨璁哄強寤鸿绛夊唴瀹广€�
鐗堟潈鎻愮ず锛氭櫤鐮斿挩璇㈠€″灏婇噸涓庝繚鎶ょ煡璇嗕骇鏉冿紝瀵规湁鏄庣‘鏉ユ簮鐨勫唴瀹规敞鏄庡嚭澶勩€傚鍙戠幇鏈珯鏂囩珷瀛樺湪鐗堟潈銆佺ǹ閰垨鍏跺畠闂锛岀儲璇疯仈绯绘垜浠紝鎴戜滑灏嗗強鏃朵笌鎮ㄦ矡閫氬鐞嗐€傝仈绯绘柟寮忥細gaojian@chyxx.com銆�010-60343812銆�