鑴傝偑鑲濈梾鏄洰鍓嶄笘鐣岃寖鍥村唴鍙戠梾鐜囨渶楂樼殑鎱㈡€ц倽鐥咃紝鍏朵腑锛屾秷鐦︾殑鑴傝偑鑲濈梾鎮ｈ€呭崰鑴傝偑鑲濈梾鎮ｈ€呮€绘暟鐨�20%锛岃惀鍏讳笉鑹殑娑堢槮浜虹兢鍑虹幇鑴傝偑鑲濈梾鐨勪綔鐢ㄦ満鍒惰繕涓嶆槑鏅般€�
杩戞棩锛屽彂琛ㄥ湪銆奙olecular Cell銆嬩笂涓€椤归涓衡€淎melioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination鈥濈殑鐮旂┒涓紝鍖椾含澶у銆佸寳澶�-娓呭崕鐢熷懡绉戝鑱斿悎涓績绉戝瀹跺彂鐜板繀闇€姘ㄥ熀閰告憚鍏ヤ笉瓒虫槸閫犳垚钀ュ吇涓嶈壇浜虹兢鎮ｄ笂鑴傝偑鑲濈梾鐨勯噸瑕佸師鍥犮€�
鐮旂┒鍥㈤槦鍒╃敤鏋滆潎骞艰櫕缁涜壊缁嗚優浣滀负鐮旂┒绯荤粺锛屽彂鐜板綋蹇呴渶姘ㄥ熀閰稿尞涔忔椂锛岃倽缁嗚優涓殑E3娉涚礌杩炴帴閰讹紙Ubr1锛夊け娲伙紝涓嶈兘鍌寲鑴傛淮淇濇姢铔嬬櫧2锛圥lin2锛夌殑澶氳仛娉涚礌鍖栭檷瑙ｃ€侾lin2铔嬬櫧姘村钩鐨勫崌楂樺垯浼氭姂鍒惰倽鑴忚剛鑲殑鍒嗚В锛屼粠鑰岄€犳垚鑴傝偑鑲濈梾銆俇br1鏄倽缁嗚優涓噸瑕佺殑蹇呴渶姘ㄥ熀閰稿彈浣擄紝鍥犳锛屽浜庤惀鍏讳笉鑹汉缇よ€岃█锛岄€傞噺琛ュ厖蹇呴渶姘ㄥ熀閰革紝瀵硅剛鑲倽鐥呯殑棰勯槻鍏锋湁閲嶈鐨勬寚瀵兼剰涔夈€�
鏈爺绌跺彂鐜版縺娲籙br1鍙互浣滀负鑴傝偑鑲濈梾娼滃湪鐨勬不鐤楃瓥鐣ワ紝鑳藉鐗瑰紓鎬х粨鍚堝苟婵€娲籙br1鐨勮剛婧舵€у皬鍒嗗瓙鏈夋湜娌荤枟鑴傝偑鑲濈梾銆�
璁烘枃閾炬帴锛�
https://doi.org/10.1016/j.molcel.2022.01.021
娉細姝ょ爺绌舵垚鏋滄憳鑷€奙olecular Cell銆嬶紝鏂囩珷鍐呭涓嶄唬琛ㄦ湰缃戠珯瑙傜偣鍜岀珛鍦猴紝浠呬緵鍙傝€冦€�
鐭ュ墠娌匡紝闂櫤鐮斻€傛櫤鐮斿挩璇㈡槸涓浗涓€娴佷骇涓氬挩璇㈡満鏋勶紝鍗佹暟骞存寔缁繁鑰曚骇涓氱爺绌堕鍩燂紝鎻愪緵娣卞害浜т笟鐮旂┒鎶ュ憡銆佸晢涓氳鍒掍功銆佸彲琛屾€х爺绌舵姤鍛婂強瀹氬埗鏈嶅姟绛変竴绔欏紡浜т笟鍜ㄨ鏈嶅姟銆備笓涓氱殑瑙掑害銆佸搧璐ㄥ寲鐨勬湇鍔°€佹晱閿愮殑甯傚満娲炲療鍔涳紝涓撴敞浜庢彁渚涘畬鍠勭殑浜т笟瑙ｅ喅鏂规锛屼负鎮ㄧ殑鎶曡祫鍐崇瓥璧嬭兘銆�
鏅虹爺鍜ㄨ - 绮惧搧鎶ュ憡
2024-2030骞翠腑鍥芥皑鍩洪吀琛屼笟甯傚満杩愯惀鏍煎眬鍙婄珵浜夋垬鐣ュ垎鏋愭姤鍛�
銆�2024-2030骞翠腑鍥芥皑鍩洪吀琛屼笟甯傚満杩愯惀鏍煎眬鍙婄珵浜夋垬鐣ュ垎鏋愭姤鍛娿€嬪叡鍗佷笁绔狅紝鍖呭惈2024-2030骞存皑鍩洪吀琛屼笟鍓嶆櫙鍙婃姇璧勪环鍊硷紝2024-2030骞存皑鍩洪吀琛屼笟鎶曡祫鏈轰細涓庨闄╅槻鑼冿紝鐮旂┒缁撹鍙婂彂灞曞缓璁瓑鍐呭銆�
鐗堟潈鎻愮ず锛氭櫤鐮斿挩璇㈠€″灏婇噸涓庝繚鎶ょ煡璇嗕骇鏉冿紝瀵规湁鏄庣‘鏉ユ簮鐨勫唴瀹规敞鏄庡嚭澶勩€傚鍙戠幇鏈珯鏂囩珷瀛樺湪鐗堟潈銆佺ǹ閰垨鍏跺畠闂锛岀儲璇疯仈绯绘垜浠紝鎴戜滑灏嗗強鏃朵笌鎮ㄦ矡閫氬鐞嗐€傝仈绯绘柟寮忥細gaojian@chyxx.com銆�010-60343812銆�
鎴戝浗绉戝瀹惰В鏋愭皑鍩洪吀鏋勫瀷瀵规尌鍙戞€ц剛鑲吀鐢熶骇鐨勫奖鍝�
