鎴戝浗绉戝瀹跺彂鐜伴潪灏忕粏鑳炶偤鐧屽绱潐閱囪€愯嵂鏂版満鍒�

鑲虹檶鏄竴绉嶅彂鐥呯巼鍜屾浜＄巼閮藉緢楂樼殑鎭舵€ц偪鐦わ紝鍏朵腑80%锝�85%涓洪潪灏忕粏鑳炶偤鐧岋紙NSCLC锛夈€傜传鏉夐唶锛圥TX锛夋槸娌荤枟鏅氭湡NSCLC鐨勪竴绾垮寲鐤楄嵂鐗┿€備絾闅忕潃娌荤枟鏃堕棿鐨勫欢闀匡紝鎮ｈ€呭鏄撳PTX浜х敓鑰愯嵂鎬э紝褰卞搷娌荤枟鏁堟灉銆傞拡瀵圭洰鍓嶅父瑙佽€愯嵂鏈哄埗鐨勬不鐤楁柟娉曞苟鏈揪鍒伴鏈熸晥鏋滐紝鍥犳锛岃揩鍒囬渶瑕佹帰绱TX鑰愯嵂鐨勫垎瀛愭満鍒讹紝鍙戠幇鏂扮殑鑰愯嵂闈剁偣鍙婃不鐤楄嵂鐗┿€�

杩戞湡锛屾矆闃宠嵂绉戝ぇ瀛︾殑绉戠爺鍥㈤槦鍙戠幇浜嗛潪灏忕粏鑳炶偤鐧屽绱潐閱囪€愯嵂鐨勬柊鏈哄埗锛岀爺绌舵垚鏋滃彂琛ㄥ湪銆奙olecular Cancer銆嬫湡鍒婏紝鏍囬涓衡€淎n EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer鈥濄€�

鐮旂┒浜哄憳閫氳繃鍩哄洜鑺墖鍒嗘瀽纭畾浜嗕箼閱涜劚姘㈤叾2锛圓LDH2锛変负PTX鑰愯嵂鎬х浉鍏冲熀鍥狅紝骞跺缁嗚優鏍€佹偅鑰呮牱鏈拰寮傜绉绘妯″瀷杩涜鍔熻兘鍒嗘瀽锛岀爺绌朵簡ALDH2鍦≒TX鑰愯嵂涓殑鍔熻兘浣滅敤銆佷复搴婃剰涔夊拰寮傚父璋冩帶鏈哄埗銆傛澶栵紝閫氳繃鐮旂┒闈跺悜ALDH2鍜岀浉鍏宠〃瑙傞仐浼犻叾鍩哄洜鐨勮嵂鐞嗗浣滅敤锛岃繘涓€姝ユ帰绱TX鑰愯嵂鎬х殑鏂版満鍒躲€�

鐮旂┒琛ㄦ槑锛孉LDH2鍦ㄩ潪灏忕粏鑳炶偤鐧屽绱潐閱囪€愯嵂杩囩▼涓捣鐫€閲嶈浣滅敤銆侫LDH2琛ㄨ揪澧炲姞锛孨SCLC缁嗚優瀵筆TX鑰愯嵂鎬у鍔犮€侫LDH2閫氳繃缁勮泲鐧界敳鍩鸿浆绉婚叾G9a/鏍歌浆褰曞洜瀛怸-伪/涔欓啗鑴辨阿閰�2锛圗HMT2/NFYA-ALDH2锛変俊鍙疯酱璋冭妭RAS锛堝ぇ榧犺倝鐦よ泲鐧斤級/RAF锛堢氦缁磋倝鐦よ泲鐧斤級淇″彿閫氳矾锛岃繘鑰岃皟鑺侼SCLC瀵筆TX鐨勮€愯嵂鎬с€傞€氳繃ALDH2鎶戝埗鍓傛垨涓嬭皟ALDH2琛ㄨ揪鍙互鎻愰珮PTX鍦∟SCLC/PTX缁嗚優鎴栧紓绉嶇Щ妞嶈偪鐦ょ殑娌荤枟鏈夋晥鎬э紝骞堕€嗚浆PTX鑰愯嵂銆�

杩欓」鐮旂┒鎻ず浜嗕竴绉嶉潪灏忕粏鑳炶偤鐧屽绱潐閱囪€愯嵂鐨勬柊鏈哄埗锛屽苟鍦ㄦ鍩虹涓婃彁鍑轰簡涓ょ閫嗚浆ALDH2浠嬪鐨凱TX鑰愯嵂鎬х殑鏂扮瓥鐣ワ紝杩欏彲鑳戒负鍏嬫湇PTX鑰愯嵂鎻愪緵浜嗘柊鐨勬€濊矾鍜岀獊鐮淬€�

璁烘枃閾炬帴锛�

https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-022-01579-9

娉細姝ょ爺绌舵垚鏋滄憳鑷€奙olecular Cancer銆嬫湡鍒婏紝鏂囩珷鍐呭涓嶄唬琛ㄦ湰缃戠珯瑙傜偣鍜岀珛鍦猴紝浠呬緵鍙傝€冦€�

鐭ュ墠娌匡紝闂櫤鐮斻€傛櫤鐮斿挩璇㈡槸涓浗涓€娴佷骇涓氬挩璇㈡満鏋勶紝鍗佹暟骞存寔缁繁鑰曚骇涓氱爺绌堕鍩燂紝鎻愪緵娣卞害浜т笟鐮旂┒鎶ュ憡銆佸晢涓氳鍒掍功銆佸彲琛屾€х爺绌舵姤鍛婂強瀹氬埗鏈嶅姟绛変竴绔欏紡浜т笟鍜ㄨ鏈嶅姟銆備笓涓氱殑瑙掑害銆佸搧璐ㄥ寲鐨勬湇鍔°€佹晱閿愮殑甯傚満娲炲療鍔涳紝涓撴敞浜庢彁渚涘畬鍠勭殑浜т笟瑙ｅ喅鏂规锛屼负鎮ㄧ殑鎶曡祫鍐崇瓥璧嬭兘銆�